Human volunteers in pharmacological experiments
نویسندگان
چکیده
منابع مشابه
Selective pharmacological activation of limbic structures in human volunteers: a positron emission tomography study.
Using a pharmacological probe, procaine hydrochloride, the authors elicited consistent and selective activation of anterior limbic and paralimbic structures in normal human volunteers as documented by H215O positron emission tomography. This activation was associated with a range of emotional, somatic, and visceral experiences, often similar to those experienced during the aura of temporal lobe...
متن کاملPharmacological experiments in healthy volunteers with bopindolol, a long-acting beta-adrenoceptor blocking drug with partial agonist activity.
Bopindolol is a potent and specific beta-adrenoceptor antagonist with partial agonist activity. In animal experiments it blocks both beta 1- and beta 2-adrenoceptors and possesses a long duration of action. In the present study in healthy volunteers bopindolol was about ten times more potent than pindolol in reducing isoprenaline-induced and exercise-induced tachycardia. In experiments on exerc...
متن کاملin Human Volunteers
The effects of endopeptidase 24.11 inhibition on angiotensin-induced changes in plasma angiotensin II, aldosterone, and atrial natriuretic factor concentrations and blood pressure were assessed in normal volunteers. Two groups, each consisting of eight normal volunteers, received stepwise infusions of angiotensin II (2, 4, and 8 ng/kg per minute) on day 5 of dose administration with 25 mg every...
متن کاملBacillary Dysentery in Human Volunteers *
In connection with a study to determine whether man could be successfully immunized against bacillary dysentery it was necessary to determine the infective dose of dysentery bacilli by feeding living Shigella to human volunteers. The only previous information concerning the susceptibility of man to experimental infection is contained in a few published observations' 3 of accidental laboratory-i...
متن کاملSucrose polyester in human volunteers.
The recent publication by Kelly et al. (1998) of their study on sucrose polyesters (SPE) raised concerns about the possible gastrointestinal (GI) and nutritional effects of olestra. These concerns were echoed in the popular press (‘Doubts raised over anti-obesity fat substitute’. The Times, 11 August 1998.). Olestra’s potential to cause GI and nutritional effects has been carefully reviewed by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of the Royal College of Psychiatrists
سال: 1986
ISSN: 0140-0789,2514-9954
DOI: 10.1192/pb.10.6.153